| 產(chǎn)品編號(hào) | bs-5135R-BF488 |
| 英文名稱 | Rabbit Anti-CREM/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的環(huán)磷酸腺苷反應(yīng)元件調(diào)節(jié)蛋白抗體 |
| 別 名 | cAMP response element modulator; CREM-1; cAMP responsive element modulator; hCREM 2; hCREM2; ICER; Inducible cAMP early repressor; Inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Pig, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CREM |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator. Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity). Subunit: Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34. Subcellular Location: Nucleus. Tissue Specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. Post-translational modifications: Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Similarity: Belongs to the bZIP family. Contains 1 bZIP domain. Contains 1 KID (kinase-inducible) domain. Database links: Entrez Gene: 1390 Human Entrez Gene: 12916 Mouse Omim: 123812 Human SwissProt: Q03060 Human SwissProt: P27699 Mouse Unigene: 200250 Human Unigene: 5244 Mouse Unigene: 10251 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CREM是一種與CREB高度同源的蛋白，與CREB均一表達(dá)于幾種細(xì)胞類型不同，其表達(dá)具有細(xì)胞特異性,CREM同CREB一樣能高效特異性結(jié)合到CRE元件上，但相反的是其下調(diào)cAMP誘導(dǎo)的轉(zhuǎn)錄. |
