| 產(chǎn)品編號(hào) |
bs-2595R-HRP |
| 英文名稱 |
Rabbit Anti-IL-1R2/HRP Conjugated antibody
|
| 中文名稱 |
辣根過氧化物酶標(biāo)記的白介素1受體2抗體 |
| 別 名 |
IL1 Receptor II; IL-1R II; IL1 Receptor 2; interleukin-1 receptor type 2 precursor; IL1R2; CD121b; IL1RB; CD121; CD121 antigen-like family member B; CD121b; CD121B Antigen; CDW121B; IL-1R-2; IL-1R-beta; IL-1R2; IL-1RT-2; IL-1RT2; IL1R Beta; Il1r-2; IL1R2; IL1RB; Interleukin 1 receptor, beta, type II; Interleukin 1 receptor, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; MGC137383; MGC47725; p68; IL1 Receptor II; IL1R2_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
免疫學(xué) 干細(xì)胞 淋巴細(xì)胞 b-淋巴細(xì)胞 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human, Rat,
(predicted: Mouse, Dog, )
|
| 產(chǎn)品應(yīng)用 |
WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
44kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human IL-1R II |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4(IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq].
Function:
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Subcellular Location:
Isoform Short: Secreted.
Isoform Long: Cell membrane; Single-pass type I membrane protein.
Post-translational modifications:
A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
Similarity:
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 7850 Human
Omim: 147811 Human
SwissProt: P27930 Human
Unigene: 25333 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IL-1RⅡ?qū)儆谛碌男盘?hào)受體家族Toll信號(hào)轉(zhuǎn)導(dǎo)通路蛋白，IL-1RⅡ在免疫和炎癥反應(yīng)的研究中占重要地位，是在很多感染 、炎癥性致病機(jī)制中起決定性作用的細(xì)胞因子，幾乎可作用于全身各種細(xì)胞，IL-1 與IL-1RⅡ的結(jié)合可導(dǎo)致大量與免疫反應(yīng)和炎癥相關(guān)基因的表達(dá) ，包括細(xì)胞因子、細(xì)胞因子受體、急性期反應(yīng)物、生長(zhǎng)因子、胞外基質(zhì)、粘附分子等。IL-1RⅡ/NF-κB信號(hào)通路是機(jī)體免疫反應(yīng)中十分重要的組成部分。
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