| 產(chǎn)品編號(hào) | bs-46011P |
| 英文名稱(chēng) | Recombinant SARS-Cov-2 Spike RBD protein (N501Y), His (HEK293) |
| 中文名稱(chēng) | 重組SARS冠狀病毒2 Spike突變蛋白R(shí)BD(N501Y) (His Tag) |
| 別 名 | SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2; 2019-nCOV Spike protein(N501Y), Recombinant (His Tag); Recombinant SARS-COV-2 S protein RBD (N501Y) Protein. ;Recombinant SARS-Cov-2 Spike RBD protein (N501Y), His (HEK293) 突變型新冠蛋白; 新冠病毒S蛋白突變體（N501Y）; 重組新冠病毒 Spike突變蛋白R(shí)BD(N501Y); 新型冠狀病毒Spike突變體蛋白; |
| 理論分子量 | 26.2kDa |
| 檢測(cè)分子量 | 35 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | ＞0.5 mg/ml |
| 物 種 | SARS-Cov-2 |
| 序 列 | 319-541/1273 |
| 純 度 | >95% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | HEK293 cell |
| 活性 | Yes |
| 標(biāo)簽 | His |
| 緩 沖 液 | Lyophilized from 0.22um filtered solution in PBS (pH7.4). Normally 5% trehalose is added as protectant before lyophilization. |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein. SWISS: P0DTC2 Gene ID: 43740568 |
