| 產(chǎn)品編號(hào) | bs-12703R |
| 英文名稱 | Plakophilin 3 Rabbit pAb |
| 中文名稱 | 橋粒斑菲素蛋白3抗體 |
| 別 名 | PKP 3; PKP3; PKP3_HUMAN; Plakophilin 3b; Plakophilin-3; Plakophilin3. |
| 研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 87 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Plakophilin 3: 631-730/797 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] Function: May play a role in junctional plaques. Subcellular Location: Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes. Tissue Specificity: Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Similarity: Belongs to the beta-catenin family. Contains 8 ARM repeats. SWISS: Q9Y446 Gene ID: 11187 Database links: Entrez Gene: 11187 Human Entrez Gene: 56460 Mouse Omim: 605561 Human SwissProt: Q9Y446 Human SwissProt: Q9QY23 Mouse Unigene: 534395 Human Unigene: 350037 Mouse Unigene: 144803 Rat |
