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SLCO1C1 Rabbit pAb (bs-11436R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號(hào) bs-11436R
英文名稱 SLCO1C1 Rabbit pAb
中文名稱 溶質(zhì)載體家族蛋白21成員1C1抗體
別    名 OATP-F; OATP1C1; OATPRP5; OATP14; organic anion transporter F; organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; SLC21A14; solute carrier family 21(organic anion transporter), member 14; solute carrier family 21 member 14; solute carrier organic anion transporter family, member 1C1; SO1C1_HUMAN .  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  通道蛋白  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 79 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLCO1C1/OATP-F: 401-500/712 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-F is a 712 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-F mediates the Na+-independent, high affinity transport of the thyroid hormones thyroxine (T4) and rT3 and other organic anions. OATP-F is also thought to transport estrone-3-sulfate and sulfobromophthalein (BSP), triiodothyronine (T3) and 17-beta-glucuronosyl estradiol at a much lower efficiency. OATP-F is expressed highly in Leydig cells in testis and in brain.

Function:
SLCO1C1 is a member of the organic anion transporter family. SLCO1C1 is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants which produce 5 distinct proteins.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus

Tissue Specificity:
Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.

Similarity:
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain.

SWISS:
Q9NYB5

Gene ID:
53919

Database links:

Entrez Gene: 518047 Cow

Entrez Gene: 53919 Human

Entrez Gene: 58807 Mouse

Entrez Gene: 84511 Rat

Omim: 613389 Human

SwissProt: Q9NYB5 Human

SwissProt: Q9ERB5 Mouse

SwissProt: Q9EPZ7 Rat

Unigene: 47261 Human

Unigene: 284495 Mouse

Unigene: 45744 Rat



產(chǎn)品圖片
Sample: Lane 1: Hela (Human) Cell Lysate at 30 ug Lane 2: SH-SY5Y (Human) Cell Lysate at 30 ug Primary: Anti- SLCO1C1 (bs-11436R) at 1/1000 dilution Anti-beta-Actin (bs-0061R) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 79 kD Observed band size: 76 kD
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