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Netrin G2 Rabbit pAb (bs-11103R)  
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產(chǎn)品編號(hào) bs-11103R
英文名稱 Netrin G2 Rabbit pAb
中文名稱 軸突生長(zhǎng)誘向因子G2/神經(jīng)突起生長(zhǎng)導(dǎo)向因子G2抗體
別    名 Laminet 2; Laminet-2; Laminet2; Lmnt2; Lmnt 2; Lmnt-2; Netrin-G2; NetrinG2; NTNG1; NTNG 1; NTNG-1; NTNG2; NTNG 2; NTNG-2; NTNG2_HUMAN; bA479K20.1; LHLL9381.  
研究領(lǐng)域 神經(jīng)生物學(xué)  生長(zhǎng)因子和激素  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Sheep,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Netrin G2: 151-250/530 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin-1, which is the mammalian homolog of UNC-6 from C. elegans, is largely expressed in the developing nervous system and in mesodermal tissues. Netrin-1 is expressed by the floor plate as either a cell associated protein or in a diffusible form, and it binds to several surface receptor components, including deleted in colorectal cancer (DCC) and neogenin. During embryonic development, netrin-1 diffuses through the neuronal epithelium, where it forms a chemoattractant gradient that directs axonal migration to the ventral midline of the spinal cord. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient.

Function:
Promotes neurite outgrowth of both axons and dendrites.

Subunit:
Interacts with LRRC4 (By similarity).

Subcellular Location:
Cell membrane.

Post-translational modifications:
N-glycosylated (By similarity).

Similarity:
Contains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.

SWISS:
Q96CW9

Gene ID:
84628

Database links:

Entrez Gene: 84628 Human

Entrez Gene: 171171 Mouse

Entrez Gene: 311836 Rat

SwissProt: Q96CW9 Human

SwissProt: Q8R4F1 Mouse

Unigene: 163642 Human

Unigene: 442448 Mouse

Unigene: 218540 Rat



產(chǎn)品圖片
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Primary: Anti-Netrin G2 (bs-11103R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kDa Observed band size: 62,50 kDa
Sample: Pituitary gland (Mouse) Lysate at 40 ug Primary: Anti- Netrin G2 (bs-11103R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kD Observed band size: 56 kD
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