| 產(chǎn)品編號(hào) | bs-1264R |
| 英文名稱 | Rabbit Anti-RSV G antibody |
| 中文名稱 | 呼吸道合胞病毒G抗體 |
| 別 名 | RS virus; RSV; GLYC_HRSVA; Major surface glycoprotein G; Attachment glycoprotein G; Membrane-bound glycoprotein; mG; G. 呼吸道合胞病毒主要表面糖蛋白G; |
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Specific References (6) | bs-1264R has been referenced in 6 publications.
[IF=20.693] Yu Mao. et al. Lung-brain axis: Metabolomics and Pathological changes in lungs and brain of Respiratory syncytial virus infected mice. J MED VIROL. 2022 Aug;: IF ; Mouse.
[IF=20.693] Pei Dai. et al. Gimap5 promoted RSV degradation through interaction with M6PR. J MED VIROL. 2022 Dec;: IF ; Mouse, Human.
[IF=6.377] Pei Dai. et al. The dispersion and utilization of lipid droplets mediates respiratory syncytial virus-induced airway hyperresponsiveness. 2021 Aug 12 IF ; Mouse.
[IF=5.758] Dai Pei. et al. The antiviral efficacies of small-molecule inhibitors against respiratory syncytial virus based on the F protein. J ANTIMICROB CHEMOTH. 2022 Nov;: IF ; Human.
[IF=5.168] Dan Liu. et al. miR-34b/c-5p/CXCL10 Axis Induced by RSV Infection Mediates a Mechanism of Airway Hyperresponsive Diseases. BIOLOGY-BASEL. 2023 Feb;12(2):317 IF ; Mouse.
[IF=3.411] Liu Dan. et al. RSV Promotes Epithelial Neuroendocrine Phenotype Differentiation through NODAL Signaling Pathway. Biomed Res Int. 2021;2021:9956078 IF ; human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 細(xì)菌及病毒 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | HRSVA |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 33kDa |
| 細(xì)胞定位 | 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human respiratory syncytial virus A2: 151-250/298 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children. RSV infection produces a variety of signs and symptoms involving different areas of the respiratory tract, from the nose to the lungs. RSV is a negative sense, enveloped RNA virus. The virion is variable in shape and size with average diameter of between 120 and 300 nm. The 63 kD RSV fusion protein of the RSS 2 strain (subtype A) directs fusion of viral and cellular membranes, results in viral penetration, and can direct fusion of infected cells with adjoining cells, resulting in the formation of syncytia or multi nucleated giant cells. Function: Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Subunit: Homooligomer. Interacts (via N-terminus) with protein M. Interacts with protein F; this interaction occurs on the surface of infected cells. Interacts with protein SH. Interacts with host CX3CR1; this interaction modulates host immune response. Subcellular Location: Virion membrane. Host cell surface. Isoform Secreted glycoprotein G: Secreted. Post-translational modifications: May carry 40-80 separate O-linked carbohydrate chains distributed among the 91 serine and threonine residues. Palmitoylated. Similarity: Belongs to the pneumoviruses glycoprotein G family. SWISS: P03423 Gene ID: N/A Database links:
呼吸道合胞病毒引起的急性呼吸道傳染病，該病毒能使病變細(xì)胞融合成多核巨細(xì)胞，故稱此名。 呼吸道合胞病毒是一種RNA病毒，屬副粘液病毒科。該病經(jīng)空氣飛沫和密切接觸傳播。多見于新生兒和6 個(gè)月以內(nèi)的嬰兒。潛伏期3～7日。嬰幼兒癥狀較重，可有高熱、鼻炎、咽炎及喉炎，以后表現(xiàn)為細(xì)支氣管炎及肺炎。少數(shù)病兒可并發(fā)中耳炎、胸膜炎及心肌炎等。成人和年長(zhǎng)兒童感染后，主要表現(xiàn)為上呼吸道感染。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Recombinant HRSVA Major surface glycoprotein G protein (HEK293)(bs-43661P)
Primary: Anti-RSV G (bs-1264R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 33 kDa
Observed band size: 90 kDa
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