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Rabbit Anti-PD-1  antibody (bs-1867R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-1867R
英文名稱 Rabbit Anti-PD-1  antibody
中文名稱 程序性死亡1(CD279)抗體
別    名 Programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD-1; hSLE1; PD 1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; Programmed cell death 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2.  
Specific References  (13)     |     bs-1867R has been referenced in 13 publications.
[IF=6.832] Aussel, Clotilde. et al. IL-1β primed mesenchymal stromal cells moderate hemorrhagic shock-induced organ injuries. Stem Cell Res Ther. 2021 Dec;12(1):1-16  FC ;  Rat.  
[IF=6.639] Ling Ding. et al. Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity. Cancers. 2021 Jan;13(22):5729  WB ;  Human.  
[IF=4.657] He, Xiaojing. et al. Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury. INFLAMMATION. 2022 Nov;:1-16  WB ;  Rat.  
[IF=4.068] Li Wang. et al. Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC. ORAL DIS. 2023 May;:  WB ;  Rat.  
[IF=3.926] Xin YAN. et al. PD-1/PD-L1 inhibition promotes hepatic regeneration in small-for-size liver following extended hepatectomy. CYTOKINE. 2022 Nov;159:156017  IHC, IF ;  Rat.  
[IF=3.376] Mirjana Nacka-Aleksi?. et al. Sex as a confounding factor in the effects of ageing on rat lymph node t cell compartment. Exp Gerontol. 2020 Dec;142:111140  FC ;  Rat.  
[IF=3.375] Fei Li. et al. POU2F1 induces the immune escape in lung cancer by up-regulating PD-L1. Am J Transl Res. 2021; 13(2): 672–683  other ;  
[IF=2.96] Zhang, Song-An, et al. "Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway." Tumor Biology 39.3 (2017): 1010428317692237.  IHC-P ;  Rat.  
[IF=2.924] Wang, Shan. et al. Excessive Immune Activation and the Correlation with Decreased Expression of PD-1 at the Maternal–Fetal Interface in Preeclampsia. REPROD SCI. 2022 Jun;:1-11  IHC ;  Human.  
[IF=2.885] Sun, Xinxin. et al. 0.1% Nano-silver mediates PD-1/PD-L1 pathway and alleviates chronic apical periodontitis in rats. ODONTOLOGY. 2022 Sep;:1-11  IHC ;  Rat.  
[IF=2.48] Szabó, Krisztina, et al. "Expansion of circulating follicular T helper cells associates with disease severity in childhood atopic dermatitis." Immunology Letters (2017).  IHC-P ;  Human.  
[IF=2.199] Yang J et al. Programmed cell death protein 1 promotes hepatitis B virus transmission through the regulation of ERK1/2-mediated trophoblasts differentiation. Arch Gynecol Obstet. 2019 Dec 2.  ICF ;  Human.  
[IF=1.808] Asuman Feda Bayrak. et al. Association of immune response with overall and disease-free survival in laryngeal squamous cell carcinomas. AM J OTOLARYNG. 2022 Jul;43:103477  IHC ;  Human.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 Flow-Cyt=1μg /test,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 32kDa
檢測(cè)分子量 55-60
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PD-1: 201-288/288 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]

Function:
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.

Subunit:
Monomer.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Ta,Ba,Ma,Thy

DISEASE:
Systemic lupus erythematosus 2 (SLEB2) [MIM:605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:12402038}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q15116

Gene ID:
5133

Database links:

Entrez Gene: 5133 Human

Entrez Gene: 18566 Mouse

Entrez Gene: 301626 Rat

Omim: 600244 Human

SwissProt: Q15116 Human

SwissProt: Q02242 Mouse

Unigene: 158297 Human

Unigene: 5024 Mouse

Unigene: 105023 Rat



產(chǎn)品圖片
Blank control (blue line): Mouse spleen cells(blue). Primary Antibody (green line): Rabbit Anti-PD-1/PE-CY7 Conjugated antibody (bs-1867R-PE-CY7) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG-PE-CY7 . Protocol The cells were fixed with 70% ice-cold methanol overnight at 4℃ . The cells were then incubated in 1 X PBS/2%BSA/10% goat serum to block non-specific protein-protein interactions followed by the antibody for 15 min at room temperature. Cells stained with Primary Antibody for 30 min at room temperature.Acquisition of 20,000 events was performed.
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